Immunoregulation therapy starting from Masato Kuwabara Ph. D’ s research of atopy set therapy and clinical application. Thereafter cooperative research with Yasuhiko Kojima Ph. D who discovered interferon and developed with pioneer in the study of immunology of specialty cytokines. This permits clinical applications. We test blood to know individual immune status and then improve unbalanced immune system by completely un-known immune cell balance and 27 article of cytokines monitoring. We succeeded to develop original 3 supplements for Immunomodulatory. This is very new treatment, but we already achieved the good results from patients who have various refractory skin diseases, atopic dermatitis skin and Chronic alopecia.